ethyl (1R,3S)-3-benzyloxycarbonylaminocyclohexanecarboxylate → (1R,3S)-ethyl 3-aminocyclohexanecarboxylate

Participants

Reaction Steps

To a solution of (1R,3S)-ethyl 3-(benzyloxycarbonylamino)cyclohexane-carboxylate, 17, (14.0 g, 45.9 mmol) in ethanol (3 mL) was added Pd/C (wet, Degussa (2.4 g, 2.3 mmol). The mixture was evacuated and then stirred under atmosphere of nitrogen at room temperature overnight. The reaction mixture was filtered through a pad of celite and the resulting filtrate concentrated in vacuo to provide an oil that was used without further purification.

Provenance & Evidence