m-Chloroperbenzoic acid → 5-chloro-3-(5-fluoro-4-(methylsulfinyl)pyrimidin-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine

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Reaction Steps

To a stirred solution of 5-chloro-3-(5-fluoro-4-(methylthio)pyrimidin-2-yl)-1-trityl-1H-pyrazolo[3,4-b]pyridine, 50, (0.078 g, 0.150 mmol) in CH2Cl2 at 0° C. was added mCPBA (0.036 g, 0.160 mmol). The mixture was kept at 0° C. for 2 hr. Then, the mixture was diluted with CH2Cl2, washed with K2CO3 (2×), dried over Na2SO4, filtered and concentrated in vacuo to provide 78 mg of the desired crude which was carried forward without further purification: LC/MS Gradient 10-90%, 0.1% formic 5 min, C18/ACN, RT=1.62 min (M+H) 554.47.

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