HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 539943Generated: October 26, 2026
1-benzyl-4-hydroxy-1,6-naphthyridin-2(1H)-one → 1,6-Naphthyridine-2,4(1H,3H)-dione
https://huagongshe.com/reaction/539943
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-benzyl-4-hydroxy-1,6-naphthyridin-2(1H)-one | HCID 71255320 | — |
| Solvent | Trifluoromethanesulfonic acid | HCID 62406 | — |
| Product | 1,6-Naphthyridine-2,4(1H,3H)-dione | HCID 69108098 | — |
Reaction Steps
A mixture of 1-benzyl-4-hydroxy-1,6-naphthyridin-2(1H)-one (21 g, 0.08 mol) and trifluoromethanesulfonic acid (100 mL) was heated with stirring at 120° C. overnight. The reaction mixture was used for the next step directly.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08871756B2 |
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| Source dataset | uspto-grants-2014_10 |
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| ORD ID | ord-6eec20b939d6490a8d658d34fc4f323a |
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| Source note | uspto-grants-2014_10 |
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