HuagongsheHuagongshe Chemistry Print Report · For research reference only
D-Psicose → N-(3-methylpyrrolidin-3-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | D-Psicose | HCID 441036 | — |
| Reactant | N-(1-benzyl-3-methylpyrrolidin-3-yl)acetamide | HCID 13787481 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-(3-methylpyrrolidin-3-yl)acetamide | HCID 15729401 | 54.1% |
Reaction Steps
A mixture of N-(1-benzyl-3-methylpyrrolidin-3-yl)-acetamide (600 mg, 2.6 mmol), palladium on carbon (400 mg, 10%) and ethanol (20 mL) was stirred at 40° C. under 50 Psi of hydrogen for 16 hours. The resulting mixture was filtrated. The filtrate was concentrated in vacuo to give 200 mg of the desired product (yield was 54%), which was used for next step without any purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871756B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-91f6fca731ee4262b602bf3a77340fe9 |
| Source note | uspto-grants-2014_10 |