反应详情

温度

60 °C

A mixture of oxetan-3-ylidene-acetonitrile (950 mg, 10 mmol) and phenylmethanamine (1.31 ml, 12 mmol) was heated with stirring at 60° C. for 5 hours under nitrogen. The mixture was concentrated in vacuo. The residue was purified by flash column (eluting with 0-50% ethyl acetate in hexane) to afford 1.65 g of 3-(benzylamino)oxetan-3-acetonitrile as a colorless oil (yield was 81.7%).

1. temperaturewas heated
2. concentrationThe mixture was concentrated in vacuo
3. customThe residue was purified by flash column (eluting with 0-50% ethyl acetate in hexane)