反应详情

温度

0 °C

To a cooled slurry of lithium aluminium hydride (327 mg, 8.6 mmol) in anhydrous diethyl ether (40 mL), was added a solution of 3-(benzylamino)oxetan-3-acetonitrile (1.0 g, 4.3 mmol) in anhydrous diethyl ether (10 mL) dropwise at 0° C. After being stirred at 0° C. for 2 hours, the reaction was quenched by introducing disodium sulfate decahydrate slowly. After being stirred for 30 minutes, the mixture was filtered, and the filter cake was washed with ethyl acetate. The filtrate was dried over sodium sulfate and concentrated in vacuo. The residue was purified by flash column to afford 800 mg of 3-(aminoethyl)-N-benzyloxetan-3-amine as a light yellow oil (yield was 79%).

1. customthe reaction was quenched
2. additionby introducing disodium sulfate decahydrate slowly
3. stirringAfter being stirred for 30 minutes
4. filtrationthe mixture was filtered
5. washthe filter cake was washed with ethyl acetate
6. dry with materialThe filtrate was dried over sodium sulfate
7. concentrationconcentrated in vacuo
8. customThe residue was purified by flash column