Ethanol → HCID 86750020, compound

HRID 54012Notes

Reaction equation

HRID 54012 reaction equation
[ClH:1].Cl.[C:3]([C:6]1[CH:7]=[CH:8][C:9]2[O:13][C:12]([CH2:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][C@H:23]4[CH2:27][CH2:26][NH:25][CH2:24]4)=[CH:18][C:17]=3[O:28][CH2:29][C:30]([OH:32])=[O:31])=[CH:11][C:10]=2[CH:33]=1)(=[NH:5])[NH2:4].S(Cl)([Cl:36])=O.[CH2:38](O)[CH3:39]>>[ClH:36].[ClH:1].[C:3]([C:6]1[CH:7]=[CH:8][C:9]2[O:13][C:12]([CH2:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]([O:22][C@H:23]4[CH2:27][CH2:26][NH:25][CH2:24]4)=[CH:18][C:17]=3[O:28][CH2:29][C:30]([O:32][CH2:38][CH3:39])=[O:31])=[CH:11][C:10]=2[CH:33]=1)(=[NH:4])[NH2:5]

Participants

4

Reactant 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 70075614HCID 70075614, compound

Product 1

HCID 86750020HCID 86750020, compound

Procedure

0.65 g of [2-[2-(5-amidino-2-benzofuranyl)ethyl]-5-[((3S)-3-pyrrolidinyl)oxy]phenyl]oxyacetic acid dihydrochloride was dissolved in 50 ml of ethanol. 0.2 ml of thionyl chloride was added to the above solution with ice cooling, and the resulting mixture was stirred at room temperature for 18 hours. Thereafter, the resulting reaction solution was concentrated to dryness, dissolved once in water, and then concentrated again to dryness. In this way, 0.65 g of the title compound was obtained in a solid form.

Workup

  1. customThereafter, the resulting reaction solution
  2. concentrationwas concentrated to dryness
  3. dissolutiondissolved once in water
  4. concentrationconcentrated again to dryness

Sources & evidence

ORD record
ord-73dce8132dc5416eb6866a95e10ce711
Source dataset
uspto-grants-1997_04
Patent number
US05620991

Reaction notes

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