反应详情

To a solution of 2-bromo-N-[2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinolin-4-yl]-2-methylpropanamide (160 mg, 0.319 mmol) in actonitrile (15 mL) was added sodium azide (62 mg, 0.958 mmol). After being refluxed overnight, the resulting mixture was concentrated in vacuo. The residue was diluted with ethyl acetate (40 mL), washed with brine, dried over sodium sulfate, and concentrated in vacuo to afford 160 mg of the crude product.

1. temperatureAfter being refluxed overnight
2. concentrationthe resulting mixture was concentrated in vacuo
3. additionThe residue was diluted with ethyl acetate (40 mL)
4. washwashed with brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo