HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichloroquinazoline → N-[(3-Aminooxetan-3-yl)methyl]-2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)quinazolin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichloroquinazoline | HCID 252886 | — |
| Reactant | 2,3,4,5-Tetrahydrobenzo[f][1,4]thiazepine 1-oxide | HCID 19608203 | — |
| Reactant | 3-(Aminomethyl)oxetan-3-amine | HCID 21713016 | — |
| Product | N-[(3-Aminooxetan-3-yl)methyl]-2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)quinazolin-4-amine | HCID 86691406 | — |
Reaction Steps
The title compound was prepared in analogy to Example 57-1 in Scheme 23 by using 2,4-dichloroquinazoline, 3-(aminomethyl)oxetan-3-amine and 2,3,4,5-tetrahydro-1,4-benzothiazepine 1-oxide. MS obsd. (ESI+) [(M+H)+] 410, 1H NMR (400 MHz, CD3OD) δ ppm 7.91-7.90 (t, J=7.2, 0.8 Hz, 1 H), 7.81-7.74 (m, 2 H), 7.58-7.54 (m, 1 H), 7.51-7.43 (m, 3 H), 7.16-7.12 (m, 1 H), 5.32-5.28 (d, J=15.2 Hz, 2 H), 4.68-4.53 (m, 6 H), 4.10 (s, 2 H), 3.37-3.34 (m, 2 H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871756B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-673c4e46c7794825988380c855bd0825 |
| Source note | uspto-grants-2014_10 |