2,3,4,5-Tetrahydrobenzo[f][1,4]thiazepine → HCID 71255066, compound

HRID 540215Notes

Reaction equation

HRID 540215 reaction equation
[CH2:1]([N:8](CC1C=CC=CC=1)[C:9]1([CH2:13][NH:14][C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([CH3:25])[CH:23]=3)[N:18]=[C:17]([N:26]3[CH2:32][C:31]4[CH:33]=[CH:34][CH:35]=[CH:36][C:30]=4[S:29](=[O:38])(=[O:37])[CH2:28][CH2:27]3)[N:16]=2)[CH2:12]OC1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClC1N=C(Cl)C2[C:49](=[CH:50]C=C(C)C=2)N=1.S1C2C=CC=CC=2CNCC1>>[CH2:1]([NH:8][C:9]1([CH2:13][NH:14][C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[C:22]([CH3:25])[CH:23]=3)[N:18]=[C:17]([N:26]3[CH2:32][C:31]4[CH:33]=[CH:34][CH:35]=[CH:36][C:30]=4[S:29](=[O:37])(=[O:38])[CH2:28][CH2:27]3)[N:16]=2)[CH2:50][CH2:49][CH2:12]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 122691062,3,4,5-Tetrahydrobenzo[f][1,4]thiazepineHCID 142564832,4-Dichloro-6-methylquinazolineHCID 71255517HCID 71255517, compound

Product 1

HCID 71255066HCID 71255066, compound

Procedure

The title compound was prepared in analogy to N-{[3-(dibenzylamino)oxetan-3-yl]methyl}-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine in Example 61-1 in Scheme 24 by using 2,4-dichloro-6-methylquinazoline, 1-(aminomethyl)-N-dibenzylcyclobutanamine and 2,3,4,5-tetrahydro-1,4-benzothiazepine.

Sources & evidence

ORD record
ord-8eb9463b1a9d41168c829219ec2e22f6
Source dataset
uspto-grants-2014_10
Patent number
US08871756B2

Reaction notes

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