[3-(Aminomethyl)oxetan-3-yl]methanamine → N-{[3-(Aminomethyl)oxetan-3-yl]methyl}-2-(2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine

Participants

Role	Name	HCID	Charge
Reactant	[3-(Aminomethyl)oxetan-3-yl]methanamine	HCID 10953471	—
Reactant	2,3,4,5-Tetrahydrobenzo[f][1,4]thiazepine	HCID 12269106	—
Reactant	2-Chloro-6-methyl-3,4-dihydroquinazolin-4-one	HCID 135588790	—
Product	N-{[3-(Aminomethyl)oxetan-3-yl]methyl}-2-(2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-methylquinazolin-4-amine	HCID 71254477	—

Reaction Steps

The title compound was prepared in analogy to Example 62-1 in Scheme 23 by using 2-chloro-6-methylquinazolin-4(3H)-one, 2,3,4,5-tetrahydro-1,4-benzothiazepine and oxetane-3,3-diyldimethanamine. MS obsd. (ESI+) [(M+H)+] 422. 1H NMR (400 MHz, CD3OD) δ ppm 7.66 (dd, J=1.6, 7.2 Hz, 1 H), 7.62 (s, 1 H), 7.44 (dd, J=1.2, 7.6 Hz, 1 H), 7.34-7.29 (m, 2 H), 7.18 (m, 1 H), 7.08 (m, 1 H), 4.99 (s, 2 H), 4.63 (d, J=6.4 Hz, 2 H), 4.45 (d, J=6.4 Hz, 2 H), 4.34 (s, 2 H), 4.02 (s, 2 H), 2.98 (s, 2 H), 2.90 (m, 2 H), 2.36 (s, 3 H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08871756B2
Source dataset	uspto-grants-2014_10
ORD ID	ord-15a8a58595c74e4390653b78be3f6c6a
Source note	uspto-grants-2014_10