N-BOC-ethylenediamine → HCID 86691423, compound

HRID 540254Notes

Reaction equation

HRID 540254 reaction equation
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:13])[CH:8]=2)[N:3]=1.[NH2:14][CH2:15][CH2:16][NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21]>CO>[Cl:1][C:2]1[N:11]=[C:10]([NH:14][CH2:15][CH2:16][NH:17][C:18](=[O:24])[O:19][C:20]([CH3:22])([CH3:21])[CH3:23])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:13])[CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 187201N-BOC-ethylenediamineHCID 142564832,4-Dichloro-6-methylquinazoline

Product 1

HCID 86691423HCID 86691423, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 2,4-dichloro-6-methylquinazoline (700 mg, 3.29 mmol), tert-butyl N-(2-aminoethyl)carbamate (2.6 g, 16.4 mmol) and methanol (35 mL) was stirred at room temperature for 1 hour. The resulting mixture was concentrated in vacuo and the residue was purified by flash column chromatography to afford 1.0 g of the product as a white solid (yield was 91%).

Workup

  1. concentrationThe resulting mixture was concentrated in vacuo
  2. customthe residue was purified by flash column chromatography

Sources & evidence

ORD record
ord-22dd8b28ded44fe19476042444a9193a
Source dataset
uspto-grants-2014_10
Patent number
US08871756B2

Reaction notes

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