HRID540262

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2757234

未命名化合物

结构：Cc1ccc2nc(N3CCS(=O)c4ccccc4C3)nc(N[C@H]3CN(C(=O)OCc4ccccc4)C[C@@H]3F)c2c1

HCID86691429

未命名化合物

结构：Cc1ccc2nc(N3CCS(=O)c4ccccc4C3)[nH]c(=O)c2c1

HCID136336798

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc2nc(N3CCS(=O)c4ccccc4C3)nc(N3CCC(NC(=O)OC(C)(C)C)C3)c2c1

HCID71262255

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to benzyl (3S,4S)-3-fluoro-4-{[6-methyl-2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)quinazolin-4-yl]amino}pyrrolidine-1-carboxylate in Example 92 by using 6-methyl-2-(1-oxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)quinazolin-4(3H)-one and tert-butyl (pyrrolidin-3-yl)carbamate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1bb20b5e56ff466c877743693101d872
来源数据集: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08871756B2
来源说明: uspto-grants-2014_10

反应 SMILES

F[C@@H]1[C@@H](NC2C3C(=CC=C(C)C=3)N=C(N3CC4C=CC=CC=4S(=O)CC3)N=2)CN(C(OCC2C=CC=CC=2)=O)C1.[CH3:41][C:42]1[CH:43]=[C:44]2[C:49](=[CH:50][CH:51]=1)[N:48]=[C:47]([N:52]1[CH2:58][C:57]3[CH:59]=[CH:60][CH:61]=[CH:62][C:56]=3[S:55](=[O:63])[CH2:54][CH2:53]1)[NH:46][C:45]2=O.[NH:65]1[CH2:69][CH2:68][CH:67]([NH:70][C:71](=[O:77])[O:72][C:73]([CH3:76])([CH3:75])[CH3:74])[CH2:66]1>>[CH3:41][C:42]1[CH:43]=[C:44]2[C:49](=[CH:50][CH:51]=1)[N:48]=[C:47]([N:52]1[CH2:58][C:57]3[CH:59]=[CH:60][CH:61]=[CH:62][C:56]=3[S:55](=[O:63])[CH2:54][CH2:53]1)[N:46]=[C:45]2[N:65]1[CH2:69][CH2:68][CH:67]([NH:70][C:71](=[O:77])[O:72][C:73]([CH3:75])([CH3:74])[CH3:76])[CH2:66]1