Acrylonitrile → HCID 71255457, compound

HRID 540268Notes

Reaction equation

HRID 540268 reaction equation
[O:1]=[S:2]1(=[O:32])[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][N:5]([C:13]2[CH:22]=[C:21]([CH2:23][CH2:24][C:25](OCC)=O)[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([CH2:30]C)[CH:19]=3)[N:14]=2)[CH2:4][CH2:3]1.ClC1C2C(=CC=C(CC)C=2)[N:37]=C(N2CC3C=CC=CC=3S(=O)(=O)CC2)C=1.C(#N)C=C>>[O:32]=[S:2]1(=[O:1])[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][N:5]([C:13]2[CH:22]=[C:21]([CH2:23][CH2:24][C:25]#[N:37])[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([CH3:30])[CH:19]=3)[N:14]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 7855AcrylonitrileHCID 71255131HCID 71255131, compoundHCID 71255557HCID 71255557, compound

Product 1

HCID 71255457HCID 71255457, compound

Procedure

The title compound was prepared in analogy to ethyl 3-[2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)-6-ethylquinolin-4-yl]propanoate in Example 95 in Scheme 46 by using 4-(4-chloro-6-ethylquinolin-2-yl)-2,3,4,5-tetrahydro-1,4-benzothiazepine 1,1-dioxide and acrylonitrile.

Sources & evidence

ORD record
ord-94c1f3653e07454da49374071e7d5f3c
Source dataset
uspto-grants-2014_10
Patent number
US08871756B2

Reaction notes

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