反应详情

To a solution of 1-bromo-2,6-dimethoxybenzene, (2.63 g, 12.1 mmol), tetrakis(triphenylphosphine)palladium (0) (0.91 g, 0.76 mol) and 1-naphthylboric acid (4.16 g, 23.9 mmol) in 1,4-dioxane (160 ml), a 2N aqueous solution of sodium hydroxide (13 ml) was added, and the mixture was heated to reflux. After cooling, the solvent was evaporated off, and the residue was dissolved in diethyl ether. The diethyl ether solution was washed with water and dried over anhydrous magnesium sulfate. Then, the solvent was evaporated off, and the residue was purified by silica gel column chromatography (developing phase: n-hexane/ethyl acetate=5/1) to obtain 1-naphthyl-2,6-dimethoxybenzene (2.50 g).

1. temperaturethe mixture was heated to reflux
2. temperatureAfter cooling
3. customthe solvent was evaporated off
4. dissolutionthe residue was dissolved in diethyl ether
5. washThe diethyl ether solution was washed with water
6. dry with materialdried over anhydrous magnesium sulfate
7. customThen, the solvent was evaporated off
8. customthe residue was purified by silica gel column chromatography (developing phase: n-hexane/ethyl acetate=5/1)