[3-(Aminomethyl)oxetan-3-yl]methanamine → HCID 71255110, compound

HRID 540292Notes

Reaction equation

HRID 540292 reaction equation
C(O[C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([C:19]([OH:21])=[O:20])[CH:17]=2)[N:12]=[C:11]([N:22]2[CH2:28][C:27]3[CH:29]=[CH:30][CH:31]=[CH:32][C:26]=3[S:25](=[O:34])(=[O:33])[CH2:24][CH2:23]2)[N:10]=1)C1C=CC=CC=1.[O:35]1[CH2:38][C:37]([CH2:41][NH2:42])([CH2:39][NH2:40])[CH2:36]1>>[NH2:40][CH2:39][C:37]1([CH2:41][NH:42][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:19]([OH:21])=[O:20])[CH:17]=3)[N:12]=[C:11]([N:22]3[CH2:28][C:27]4[CH:29]=[CH:30][CH:31]=[CH:32][C:26]=4[S:25](=[O:34])(=[O:33])[CH2:24][CH2:23]3)[N:10]=2)[CH2:38][O:35][CH2:36]1

Participants

3

Reactant 2

HCID 10953471[3-(Aminomethyl)oxetan-3-yl]methanamineHCID 86691434HCID 86691434, compound

Product 1

HCID 71255110HCID 71255110, compound

Procedure

The title compound was prepared in analogy to Example 108-1 in Scheme 54 by using 4-(benzyloxy)-2-(1,1-dioxido-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)quinazoline-6-carboxylic acid and oxetane-3,3-diyldimethanamine, MS obsd. (ESI+) [(M+H)+] 484, 1H NMR (400 MHz, DMSO-d6) δ ppm 8.95 (brs, 1 H), 8.68 (m, 1 H), 8.04 (d, J=9.1 Hz, 1 H), 7.77-7.73 (m, 2 H), 7.68-7.63 (m, 1 H), 7.48-7.43 (m, 1 H), 7.24-7.19 (m, 1 H), 5.11 (brs, 2 H), 4.59-4.30 (brs, 6 H), 4.20 (m, 1 H), 4.0 (m, 1 H), 3.58 (brs, 2 H), 3.12 (m, 2 H).

Sources & evidence

ORD record
ord-4b78c13e87684d5d83ba56ed856590e2
Source dataset
uspto-grants-2014_10
Patent number
US08871756B2

Reaction notes

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