HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichloro-6-methylquinoline → (E)-2-(4-chloro-6-methylquinolin-2-yl)-N-methoxy-3,4-dihydro-1H-2-benzazepin-5-imine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichloro-6-methylquinoline | HCID 2754668 | — |
| Reactant | 2-(4-chloro-6-methylquinolin-2-yl)-5,5-difluoro-2,3,4,5-tetrahydro-1H-benzazepine | HCID 71255094 | — |
| Reactant | N-methoxy-1,2,3,4-tetrahydro-5H-2-benzazepin-5-imine | HCID 86691438 | — |
| Reactant | N-[(3-aminooxetan-3-yl)methyl]-2-[(5E)-5-methoxyimino-3,4-dihydro-1H-2-benzazepin-2-yl]-6-methylquinolin-4-amine | HCID 89406081 | — |
| Product | (E)-2-(4-chloro-6-methylquinolin-2-yl)-N-methoxy-3,4-dihydro-1H-2-benzazepin-5-imine | HCID 89406036 | — |
Reaction Steps
The title compound was prepared in analogy to 2-(4-chloro-6-methylquinolin-2-yl)-5,5-difluoro-2,3,4,5-tetrahydro-1H-benzazepine in Example 110-1 in Scheme 56 by using 2,4-dichoro-6-methylquinoline and N-methoxy-1,2,3,4-tetrahydro-5H-2-benzazepin-5-imine. N-[(3-Aminooxetan-3-yl)methyl]-2-[(5E)-5-(methoxyimino)-1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl]-6-methylquinolin-4-amine
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871756B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-11fbfbfcdc024069ace7c9145850fe27 |
| Source note | uspto-grants-2014_10 |