3-(Aminomethyl)oxetan-3-amine → HCID 71255565, compound

HRID 540298Notes

Reaction equation

HRID 540298 reaction equation
O[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH3:12])[CH:10]=2)[N:5]=[C:4]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[C:16]3[CH:21]=[CH:22][CH:23]=[CH:24][C:15]=3[CH2:14]2)[N:3]=1.[NH2:25][CH2:26][C:27]1([NH2:31])[CH2:30][O:29][CH2:28]1>>[NH2:31][C:27]1([CH2:26][NH:25][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([CH3:12])[CH:10]=3)[N:5]=[C:4]([N:13]3[CH2:19][CH2:18][C:17](=[O:20])[C:16]4[CH:21]=[CH:22][CH:23]=[CH:24][C:15]=4[CH2:14]3)[N:3]=2)[CH2:30][O:29][CH2:28]1

Participants

3

Reactant 2

HCID 217130163-(Aminomethyl)oxetan-3-amineHCID 178423399HCID 178423399, compound

Product 1

HCID 71255565HCID 71255565, compound

Procedure

The title compound was prepared in analogy to Example 62-1 in Scheme 23 by using 2-(4-hydroxy-6-methylquinazolin-2-yl)-1,2,3,4-tetrahydro-5H-2-benzazepin-5-one and 3-(aminomethyl)oxetan-3-amine. MS obsd. (ESI+) [(M+H)+] 404, 1H NMR (400 MHz, CD3OD) δ ppm 7.94 (s, 1 H), 7.90 (d, 1 H), 7.75 (d, 1 H), 7.65-7.55 (m, 3 H), 7.45 (t, 1 H), 5.40 (s, 2 H), 4.77-7.72 (m, 4 H), 4.40 (s, 2 H), 4.05 (brs, 2 H), 3.35 (t, 2 H), 2.43 (s, 3 H).

Sources & evidence

ORD record
ord-f8643eddd6294f05bb328c421da045fe
Source dataset
uspto-grants-2014_10
Patent number
US08871756B2

Reaction notes

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