反应详情

温度

160 °C

The mixture of 2,4-dichloro-6-methyl-quinoline (422 mg, 2 mmol), 1,3,4,5-tetrahydro-2H-1,4-benzodiazepin-2-one (298 mg, 2 mmol) and n-butyl alcohol (15 mL) was heated with stirring in a 20 mL microwave process vial for 3 hours at 160° C. under microwave irradiation. After cooling, the solvent was removed in vacuo and the residue was purified by column chromatography on silica gel (methanol/dichloromethane, 1:20) to give the product. MS obsd. (ESI+) [(M+H)+] 338.

1. temperaturewas heated
2. temperatureAfter cooling
3. customthe solvent was removed in vacuo
4. customthe residue was purified by column chromatography on silica gel (methanol/dichloromethane, 1:20)
5. customto give the product