反应详情

温度

20 °C

Racemic ibuprofen (18.03 g, 87.4 mmol), N-methyl-D-glucamine (8.2 g, 42 mmol), water (0.5 mL), and toluene (150 mL) were heated to 50° C., forming a clear solution. The solution was cooled to 20° C., then in an ice bath, and allowed to stand for 48 hours. The resulting crystalline precipitate was recovered by filtration at 20° C., washed with toluene (30 mL), and dried to give (S)-ibuprofen N-methyl-D-glucamine salt (11.9 g, 68% yield, 92% ee).

1. customforming a clear solution
2. customin an ice bath, and allowed
3. filtrationThe resulting crystalline precipitate was recovered by filtration at 20° C.
4. washwashed with toluene (30 mL)
5. customdried