HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3-Cyclohexylazetidin-3-ol trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 3-Cyclohexyl-3-hydroxy-1-(tert-butoxycarbonyl)azetidine | HCID 65919409 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Cyclohexylazetidin-3-ol trifluoroacetate | HCID 66988412 | — |
Reaction Steps
1 ml of trifluoroacetic acid is added to a solution containing 120 mg (0.47 mmol) of 3-cyclohexyl-3-hydroxy-1-(tert-butoxycarbonyl)azetidine dissolved in 3 ml of dichloromethane. The reaction medium is stirred at ambient temperature for 1 hour and then concentrated to dryness and used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871187B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-e8444eb0ec484519bd17a0bb83406124 |
| Source note | uspto-grants-2014_10 |