HCID 178525677, compound → HCID 178525678, compound

HRID 540397Notes

Reaction equation

HRID 540397 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH:8]1[CH:12]=[C:11]([CH:13]=[CH:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])[N:10]=[CH:9]1>[Pd].C(O)(=O)C>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH:8]1[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])[N:10]=[CH:9]1

Participants

4

Reactant 1

HCID 178525677HCID 178525677, compound

Product 1

HCID 178525678HCID 178525678, compoundYield 80%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

4 ml of acetic acid and 80 mg of palladium-on-charcoal at 10% are added to 218 mg (0.741 mmol) of 6-(1H-imidazol-4-yl)hex-5-enoic acid trifluoroacetate. The reaction medium is placed under a hydrogen atmosphere at atmospheric pressure. After 13 hours, the reaction medium is filtered through celite. After the solvents have been evaporated off, 175 mg of 6-(1H-imidazol-4-yl)hexanoic acid trifluoroacetate in the form of a yellow oil are obtained with a yield of 80%.

Workup

  1. filtrationthe reaction medium is filtered through celite
  2. customAfter the solvents have been evaporated off

Sources & evidence

ORD record
ord-03e707e0133f495e83cd276dd24f62d9
Source dataset
uspto-grants-2014_10
Patent number
US08871187B2

Reaction notes

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