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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 540636Generated: October 26, 2026

(Triphenylphosphoranylidene)acetaldehyde → (E)-3-[5-(3-Fluorophenyl)pyridin-2-yl]propenal

https://huagongshe.com/reaction/540636

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(Triphenylphosphoranylidene)acetaldehydeHCID 75051—
Reactant5-(3-Fluorophenyl)pyridine-2-carbaldehydeHCID 46313112—
Product(E)-3-[5-(3-Fluorophenyl)pyridin-2-yl]propenalHCID 86676729—

Reaction Steps

584 mg of 5-(3-fluorophenyl)pyridine-2-carbaldehyde and 883 mg of (triphenylphosphoranylidene)acetaldehyde are stirred at RT overnight. The solvents are evaporated and the residue is purified by column chromatography (silica gel, MeOH:DCM=99.5:0.5).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08871798B2
Source datasetuspto-grants-2014_10
ORD IDord-d225d56d701c4882a7a3c0a75e369b6c
Source noteuspto-grants-2014_10