反应详情

A mixture of 235 mg of (E)-3-[5-(3-fluorophenyl)pyridin-2-yl]propenal, 133 mg of D-pipecolinic acid, 115 mg of N-methylmaleimide and 30 ml of MeCN is heated at the boil for 2 h. The volatile components are removed under reduced pressure and the residue is purified by column chromatography (silica gel, MeOH:DCM=97:3). In this manner, 2 pure fractions are isolated.

1. temperatureis heated at the boil for 2 h
2. customThe volatile components are removed under reduced pressure
3. customthe residue is purified by column chromatography (silica gel, MeOH:DCM=97:3)
4. customIn this manner, 2 pure fractions are isolated