反应详情

A mixture of 820 mg of (E)-3-(5-bromopyridin-2-yl)propenal, 500 mg of D-pipecolinic acid, 430 mg of N-methylmaleinimide and 20 ml of MeCN is boiled at reflux for 2 h. The solvents are removed and the residue is purified by column chromatography (silica gel, ethyl acetate:DCM=3:1). Using this method, 3 pure fractions are obtained.

1. temperatureat reflux for 2 h
2. customThe solvents are removed
3. customthe residue is purified by column chromatography (silica gel, ethyl acetate:DCM=3:1)
4. customare obtained