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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 540640Generated: October 30, 2026

N-Methylmaleimide → 7-Hydroxy-2-methyl-4-[(E)-2-(6-methylpyridin-2-yl)vinyl]hexahydropyrrolo[3,4-a]pyrrolizine-1,3-dione

https://huagongshe.com/reaction/540640

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-MethylmaleimideHCID 70261—
ReactantCis-4-Hydroxy-L-ProlineHCID 440015—
Reactant3-(6-Methylpyridin-2-yl)prop-2-enalHCID 45079695—
Product7-Hydroxy-2-methyl-4-[(E)-2-(6-methylpyridin-2-yl)vinyl]hexahydropyrrolo[3,4-a]pyrrolizine-1,3-dioneHCID 53492434—

Reaction Steps

The title compound is prepared analogously from 100 mg of (E)-3-(6-methylpyridin-2-yl)propenal, 75 mg of N-methylmaleimide and 100 mg of cis-4-hydroxy-L-proline.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08871798B2
Source datasetuspto-grants-2014_10
ORD IDord-159b65e2ded74b23a15e8ebf36d838b2
Source noteuspto-grants-2014_10