反应详情

A mixture of 100 mg of (E)-3-[5-(3-fluorophenyl)pyridin-2-yl]propenal, 64 mg of (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid, 54 mg of N-methylmaleimide and 4 ml of MeCN is heated at the boil for 4 h. The volatile components are removed under reduced pressure and the residue is purified by column chromatography (silica gel, MeOH:DCM=5:95). In this manner, 4 pure fractions are isolated as racemic mixtures.

1. temperatureis heated at the boil for 4 h
2. customThe volatile components are removed under reduced pressure
3. customthe residue is purified by column chromatography (silica gel, MeOH:DCM=5:95)
4. customIn this manner, 4 pure fractions are isolated as racemic mixtures