Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 540643Generated: October 27, 2026

2-Methoxyphenylboronic acid → 4-{(E)-2-[5-(2-Methoxyphenyl)pyridin-2-yl]vinyl}-2-methyloctahydropyrrolo[3,4-a]-indolizine-1,3-dione

https://huagongshe.com/reaction/540643

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methoxyphenylboronic acidHCID 2733958—
Reactant4-[(E)-2-(5-bromopyridin-2-yl)vinyl]-2-methyloctahydropyrrolo[3,4-a]-indolizine-1,3-dioneHCID 53492368—
Reactant2-Methyl-4-{(E)-2-[5-(3-trifluoromethyl phenyl)pyridin-2-yl]vinyl}octahydropyrrolo[3,4-a]indolizine-1,3-dioneHCID 53492504—
Product4-{(E)-2-[5-(2-Methoxyphenyl)pyridin-2-yl]vinyl}-2-methyloctahydropyrrolo[3,4-a]-indolizine-1,3-dioneHCID 53492505—

Reaction Steps

The title compound is prepared analogously to the compound from Example 17 from 42 mg of 4-[(E)-2-(5-bromopyridin-2-yl)vinyl]-2-methyloctahydropyrrolo[3,4-a]-indolizine-1,3-dione (from Example 6, racemic mixture 3) and 18 mg of 2-methoxyphenylboronic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08871798B2
Source datasetuspto-grants-2014_10
ORD IDord-9789b3df6a964cff8c596ca8b1d1f642
Source noteuspto-grants-2014_10