HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chlorophenylboronic acid → 4-{(E)-2-[5-(2-Chlorophenyl)pyridin-2-yl]vinyl}-2-methyloctahydropyrrolo[3,4-a]-indolizine-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chlorophenylboronic acid | HCID 2734322 | — |
| Reactant | 4-[(E)-2-(5-bromopyridin-2-yl)vinyl]-2-methyloctahydropyrrolo[3,4-a]-indolizine-1,3-dione | HCID 53492368 | — |
| Reactant | 2-Methyl-4-{(E)-2-[5-(3-trifluoromethyl phenyl)pyridin-2-yl]vinyl}octahydropyrrolo[3,4-a]indolizine-1,3-dione | HCID 53492504 | — |
| Product | 4-{(E)-2-[5-(2-Chlorophenyl)pyridin-2-yl]vinyl}-2-methyloctahydropyrrolo[3,4-a]-indolizine-1,3-dione | HCID 53492566 | — |
Reaction Steps
The title compound is prepared analogously to the compound from Example 17 from 42 mg of 4-[(E)-2-(5-bromopyridin-2-yl)vinyl]-2-methyloctahydropyrrolo[3,4-a]-indolizine-1,3-dione (from Example 6, racemic mixture 3) and 18 mg of 2-chloro-phenylboronic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871798B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-69869425d42c49b7acc0d1eac225345e |
| Source note | uspto-grants-2014_10 |