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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 540645Generated: October 26, 2026

Thiophene-3-boronic acid → 2-Methyl-4-[(E)-2-(5-thiophen-3-ylpyridin-2-yl)vinyl]octahydropyrrolo[3,4-a]indolizine-1,3-dione

https://huagongshe.com/reaction/540645

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThiophene-3-boronic acidHCID 581760—
Reactant4-[(E)-2-(5-bromopyridin-2-yl)vinyl]-2-methyloctahydropyrrolo[3,4-a]-indolizine-1,3-dioneHCID 53492368—
Reactant2-Methyl-4-{(E)-2-[5-(3-trifluoromethyl phenyl)pyridin-2-yl]vinyl}octahydropyrrolo[3,4-a]indolizine-1,3-dioneHCID 53492504—
Product2-Methyl-4-[(E)-2-(5-thiophen-3-ylpyridin-2-yl)vinyl]octahydropyrrolo[3,4-a]indolizine-1,3-dioneHCID 53492567—

Reaction Steps

The title compound is prepared analogously to the compound from Example 17 from 42 mg of 4-[(E)-2-(5-bromopyridin-2-yl)vinyl]-2-methyloctahydropyrrolo[3,4-a]-indolizine-1,3-dione (from Example 6, racemic mixture 3) and 15 mg of 3-thiophene-boronic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08871798B2
Source datasetuspto-grants-2014_10
ORD IDord-ed6b7522708b46f18216da766e191456
Source noteuspto-grants-2014_10