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HRID540646

反应详情

EQUATION

反应方程式

HRID 540646 的结构方程式

REACTANTS

反应物

3
结构：CN1C(=O)C=CC1=O
HCID70261

Maleimide, N-methyl-

C5H5NO2

结构：Cl.O=C(O)C1CC=CCN1
HCID67783700

2-Pyridinecarboxylic acid, 1,2,3,6-tetrahydro-, hydrochloride (1:1)

C6H10ClNO2

结构：O=C/C=C/c1ccc(-c2cccc(F)c2)cn1
HCID86676729

未命名化合物

PRODUCTS

生成物

1
结构：CN1C(=O)C2C(C1=O)C1CC=CCN1C2/C=C/c1ccc(-c2cccc(F)c2)cn1
HCID53492568

未命名化合物

PROCEDURE

实验过程

The title compound is prepared analogously from 100 mg of (E)-3-[5-(3-fluorophenyl)pyridin-2-yl]propenal, 49 mg of N-methylmaleimide and 58 mg of 1,2,3,6-tetrahydropyridine-2-carboxylic acid hydrochloride. The crude product is purified by column chromatography (silica gel, MeOH:DCM=2:98). In this manner, 3 pure fractions are isolated as racemic mixtures.

WORKUP

后处理

  1. customThe crude product is purified by column chromatography (silica gel, MeOH:DCM=2:98)
  2. customIn this manner, 3 pure fractions are isolated as racemic mixtures