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HRID54067

反应详情

EQUATION

反应方程式

HRID 54067 的结构方程式

REACTANTS

反应物

2
结构：[K+].[OH-]
HCID14797

Potassium hydroxide

HKO

结构：O=C(N[C@@H](Cc1ccccc1)[C@H](O)CCl)OCc1ccccc1
HCID10860587

Benzyl [(2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl]carbamate

C18H20ClNO3

PRODUCTS

生成物

1
结构：O=C(N[C@@H](Cc1ccccc1)[C@H]1CO1)OCc1ccccc1
HCID9861019

Phenylmethyl N-[(1S)-1-[(2S)-2-oxiranyl]-2-phenylethyl]carbamate

C18H19NO3

收率 99.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A solution of 11.4 g of 3(S)-(benzyloxyformamido)-1-chloro-4-phenyl-2(S)-butanol in 300 ml of ethanol containing 2.24 g of potassium hydroxide was left to stand for 15 minutes. The solvent was removed by evaporation and the residue was partitioned between water and dichloromethane. Working-up gave 10.1 g of crude 3(S)-(benzyloxyformamido)-1,2(S)-epoxy-4-phenylbutane as an off-white solid which was used without further purification.

WORKUP

后处理

  1. customThe solvent was removed by evaporation
  2. customthe residue was partitioned between water and dichloromethane