HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → benzyl [2-(4-methoxyphenyl)-l(S)-(2-diazoacetyl)ethyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | (2S)-2-{[(benzyloxy)carbonyl]amino}-3-(4-methoxyphenyl)propanoic acid | HCID 10496574 | — |
| Product | benzyl [2-(4-methoxyphenyl)-l(S)-(2-diazoacetyl)ethyl]carbamate | HCID 53748252 | — |
Reaction Steps
In a manner analogous to that described in Example 19(i), 3.10 g of N-(benzyloxycarbonyl)-3-(4-methoxyphenyl)-L-alanine were treated with isobutyl chloroformate followed by diazomethane to give 2.83 g of benzyl [2-(4-methoxyphenyl)-1(S)-(2-diazoacetyl)ethyl]carbamate as a pale yellow solid of melting point 88°-90° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05620987 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-35f49ed163ac44408ab12a6e1f96695d |
| Source note | uspto-grants-1997_04 |