HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → benzyl [2-(4-tert.butoxyphenyl)-1(S)-(2-diazoacetyl)ethyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | O-(1,1-Dimethylethyl)-N-((phenylmethoxy)carbonyl)-L-tyrosine | HCID 978520 | — |
| Reactant | 15-Hydroxy Lubiprostone Dicyclohexylammonium Salt | HCID 71749095 | — |
| Product | benzyl [2-(4-tert.butoxyphenyl)-1(S)-(2-diazoacetyl)ethyl]carbamate | HCID 57129157 | — |
Reaction Steps
In a manner analogous to that described in Example 19(i), N-(benzyloxycarbonyl)-3-(4-tert.butoxyphenyl)-L-alanine (prepared from 7.45 g of the dicyclohexylammonium salt) was treated with isobutyl chloroformate followed by reaction with diazomethane to give 3.58 g of benzyl [2-(4-tert.butoxyphenyl)-1(S)-(2-diazoacetyl)ethyl]carbamate as a yellow solid of melting point 80°-82° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05620987 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-f9561df5dbdd4dd4856abed8b7c7ebf4 |
| Source note | uspto-grants-1997_04 |