4-Fluorobenzaldehyde → 3-[1-ethyl-5-(4-formylphenoxy)-1H-pyrazol-3-yl]benzonitrile

HRID 540761Notes

Reaction equation

HRID 540761 reaction equation
[CH2:1]([N:3]1[C:7](=[O:8])[CH:6]=[C:5]([C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[NH:4]1)[CH3:2].F[C:18]1[CH:25]=[CH:24][C:21]([CH:22]=[O:23])=[CH:20][CH:19]=1>>[CH2:1]([N:3]1[C:7]([O:8][C:18]2[CH:25]=[CH:24][C:21]([CH:22]=[O:23])=[CH:20][CH:19]=2)=[CH:6][C:5]([C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])=[N:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 680234-FluorobenzaldehydeHCID 671110593-(1-ethyl-5-oxo-2,5-dihydro-1H-pyrazol-3-yl)benzonitrile

Product 1

HCID 772311493-[1-ethyl-5-(4-formylphenoxy)-1H-pyrazol-3-yl]benzonitrile

Procedure

3-[1-ethyl-5-(4-formylphenoxy)-1H-pyrazol-3-yl]benzonitrile was prepared from 3-(1-ethyl-5-oxo-2,5-dihydro-1H-pyrazol-3-yl)benzonitrile and 4-fluorobenzaldehyde with a procedure similar to Example 1, Step 3. Calc'd (M+1) 318.1. Found: 318.0

Sources & evidence

ORD record
ord-416ea545452a4ce58898ccf228708252
Source dataset
uspto-grants-2014_10
Patent number
US08871796B2

Reaction notes

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