反应详情

温度

50 °C

Acetic anhydride (0.24 mL, 3.3 mmol, 0.1 equiv) was added to a stirring solution of 3-[1-ethyl-5-(4-formylphenoxy)-1H-pyrazol-3-yl]benzonitrile (10.5 g, 33.0 mmol, 1 equiv) in methanol (66 mL). 4A molecular sieves were then added and the mixture was stirred at 50° C. for 3 hours. The sieves were filtered away and the filtrate was purified by flash chromatography (0-40% EtOAc:Hex) to give 3-{5-[4-(dimethoxymethyl)phenoxy]-1-ethyl-1H-pyrazol-3-yl}benzonitrile (77% yield). Calc'd (M+1) 364.2. Found: 364.1

1. filtrationThe sieves were filtered away
2. customthe filtrate was purified by flash chromatography (0-40% EtOAc:Hex)