Dichloromethane → HCID 52913256, compound

Participants

Reaction Steps

A solution of N-[2-(3-{1-ethyl-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)propan-2-yl]-2,2,2-trifluoroethanesulfonamide (560 mg, 10.5 mmol) and DCM (6.97 mL) was cooled to 0° C., treated with NIS (706 mg, 3.14 mmol) in a single portion. The mixture was protected from light and allowed to warm to rt as it was stirred overnight. The reaction was diluted with EtOAc and washed with water 2×, sat. aq. NaHCO3, brine, dried (MgSO4) and concentrated to afford a white solid purified via MPLC, 25 g silica, 10-60% EtOAc in heptanes to afford a white solid: MS: cal'd 662 (MH+), exp 662 (MH+).

Provenance & Evidence