HCID 52913256, compound → HCID 52913259, compound

Participants

Reaction Conditions

Reaction Steps

A solution of N-[2-(3-{1-ethyl-4-iodo-5-[4-(trifluoromethyl)phenoxy]-1H-pyrazol-3-yl}phenyl)propan-2-yl]-2,2,2-trifluoroethanesulfonamide (51.2 mg, 0.077 mmol) and pyridine (387 μL) was treated with copper (I) phenylacetylide (12 mg, 0.085 mmol), degassed with argon, sealed in a microwave vial and heated to 100° C. via a block heater. After 2 days the resulting brown solution was cooled, diluted with EtOAc, washed with 50% sat. aq. NaHCO3 2×, sat. aq NaHCO3, dried (MgSO4) and concentrated to afford a black residue purified via MPLC, 10 g silica, 5-30% EtOAc in heptanes to afford a light yellow solid: MS: cal'd 636 (MH+), exp 636 (MH+).

Provenance & Evidence