Sodium Sulfite → HCID 178452606, compound

Participants

Reaction Steps

A stirred solution of tert-butyl {3-[3-(1-ethenyl-5-(4-trifluoromethylphenoxy)-1H-pyrazol-3-yl)phenyl]oxetan-3-yl}carbamate (1.02 g, 2.03 mmol) in 14 mL of 2.5:1 acetone:water was cooled in an ice bath. To the stirred solution was added OsO4 (2.6 mL of a 5.5 weight % solution in water, 0.2 mmol) and N-methylmorpholine N-oxide (2.4 g, 2.1 mmol). The mixture was stirred for 3.5 h. 10% Aqueous Na2SO3 solution was added. The mixture was stirred for 5 min, then extracted with EtOAc. The combined organic phases were washed with water and brine, then dried over MgSO4, filtered, and the solvents were removed under reduced pressure to give tert-butyl {3-[3-(5-(4-trifluoromethylphenoxy)-1H-pyrazol-3-yl)phenyl]oxetan-3-yl}carbamate as a dark solid. Calcd (M+1)+: 476.5. Found: 476.2

Provenance & Evidence