Tert-butyl 4-(2-iodoethyl)piperidine-1-carboxylate → tert-butyl 4-(2-{[2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-7-yl]oxy}ethyl)piperidine-1-carboxylate

HRID 540834Notes

Reaction equation

HRID 540834 reaction equation
[CH3:1][C:2]1[N:3]([CH2:16][CH:17]([CH3:19])[CH3:18])[C:4]2[C:13]3[CH:12]=[CH:11][C:10]([OH:14])=[CH:9][C:8]=3[N:7]=[CH:6][C:5]=2[N:15]=1.I[CH2:21][CH2:22][CH:23]1[CH2:28][CH2:27][N:26]([C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[CH2:25][CH2:24]1>>[CH3:1][C:2]1[N:3]([CH2:16][CH:17]([CH3:19])[CH3:18])[C:4]2[C:13]3[CH:12]=[CH:11][C:10]([O:14][CH2:21][CH2:22][CH:23]4[CH2:24][CH2:25][N:26]([C:29]([O:31][C:32]([CH3:33])([CH3:35])[CH3:34])=[O:30])[CH2:27][CH2:28]4)=[CH:9][C:8]=3[N:7]=[CH:6][C:5]=2[N:15]=1

Participants

3

Reactant 2

HCID 9974426Tert-butyl 4-(2-iodoethyl)piperidine-1-carboxylateHCID 1363405372-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-7-ol

Product 1

HCID 68972628tert-butyl 4-(2-{[2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-7-yl]oxy}ethyl)piperidine-1-carboxylate

Procedure

The general method described in Part L of Example 2 was used to treat 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-7-ol with tert-butyl 4-(2-iodoethyl)piperidine-1-carboxylate. After chromatographic purification, tert-butyl 4-(2-{[2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-7-yl]oxy}ethyl)piperidine-1-carboxylate was isolated as a viscous, orange oil.

Workup

  1. customAfter chromatographic purification

Sources & evidence

ORD record
ord-38b33a6b0a804612b35d89e8733a8811
Source dataset
uspto-grants-2014_10
Patent number
US08871782B2

Reaction notes

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