HCID 58833624, compound → HCID 69507043, compound

HRID 540836Notes

Reaction equation

HRID 540836 reaction equation
CC1[N:3](CC(C)C)C2C3C=CC(OCCC4CCNCC4)=CC=3N=C(N)C=2N=1.[CH3:29][C:30]1[N:31]([CH2:61][CH:62]([CH3:64])[CH3:63])[C:32]2[C:41]3[CH:40]=[CH:39][C:38]([O:42][CH2:43][CH2:44][CH:45]4[CH2:50][CH2:49][N:48]([C:51]([N:53]5[CH2:58][CH2:57][O:56][CH2:55][CH2:54]5)=[O:52])[CH2:47][CH2:46]4)=[CH:37][C:36]=3[N:35]=[C:34](N)[C:33]=2[N:60]=1>>[CH3:29][C:30]1([NH2:3])[NH:60][C:33]2[CH:34]=[N:35][C:36]3[CH:37]=[C:38]([O:42][CH2:43][CH2:44][CH:45]4[CH2:50][CH2:49][N:48]([C:51]([N:53]5[CH2:58][CH2:57][O:56][CH2:55][CH2:54]5)=[O:52])[CH2:47][CH2:46]4)[CH:39]=[CH:40][C:41]=3[C:32]=2[N:31]1[CH2:61][CH:62]([CH3:64])[CH3:63]

Participants

3

Reactant 2

HCID 58833624HCID 58833624, compoundHCID 58833686HCID 58833686, compound

Product 1

HCID 69507043HCID 69507043, compound

Procedure

A modification of the method described in Example 19 was used to convert 2-methyl-1-(2-methylpropyl)-7-(2-piperidin-4-ylethoxy)-1H-imidazo[4,5-c]quinolin-4-amine to 0.195 g of 2-methyl-1-(2-methylpropyl)-7-{2-[1-(morpholin-4-ylcarbonyl)piperidin-4-yl]ethoxy}-1H-imidazo[4,5-c]quinolin-4-amine, which was isolated an off-white powder, mp 205-208° C. The product was not recrystallized.

Workup

  1. customwhich was isolated an off-white powder, mp 205-208° C
  2. customThe product was not recrystallized

Sources & evidence

ORD record
ord-f6c02dedfe474fcab11d69542aa8dd1b
Source dataset
uspto-grants-2014_10
Patent number
US08871782B2

Reaction notes

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