反应详情

D-tryptophan (100 g) was suspended in methanol (500 mL) and the suspension was added to a solution of thionyl chloride (82.14 g) in methanol (500 mL) at 25° C. to 30° C. under nitrogen atmosphere. The resultant solution was stirred at reflux for 3 to 4 hours and the reaction mixture was concentrated to a residual volume of 150 mL. To the concentrated mixture, dichloromethane (700 mL) was added and the resultant solution was cooled to 0° C. to 5° C. with continuous stirring for 0.5 hours. The solid so obtained was filtered, washed with dichloromethane (200 mL), and dried in air at 40° C. to 45° C. to afford D-tryptophan methyl ester hydrochloride.

1. temperatureat reflux for 3 to 4 hours
2. concentrationthe reaction mixture was concentrated to a residual volume of 150 mL
3. additionTo the concentrated mixture, dichloromethane (700 mL) was added
4. temperaturethe resultant solution was cooled to 0° C. to 5° C.
5. customThe solid so obtained
6. filtrationwas filtered
7. washwashed with dichloromethane (200 mL)
8. customdried in air at 40° C. to 45° C.