HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Naphthoyl chloride → 3-cyano-N-(2-naphthoyl)-L-alanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Naphthoyl chloride | HCID 75246 | — |
| Reactant | 3-cyano-L-alanine | HCID 439742 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 3-cyano-N-(2-naphthoyl)-L-alanine | HCID 53874508 | 18.3% |
Reaction Steps
0.114 g of 3-cyano-L-alanine was dissolved in 5 ml of 1N sodium hydroxide solution and treated with 0.285 g of 2-naphthoyl chloride at 0° C. After acidification with 2M hydrochloric acid and flash chromatography on silica gel using 25% methanol in dichloromethane for the elution there was obtained 0.049 g of 3-cyano-N-(2-naphthoyl)-L-alanine of melting point 95°-100° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05620987 |
| Source dataset | uspto-grants-1997_04 |
| ORD ID | ord-68ceea45c60646408b112a18b1611e95 |
| Source note | uspto-grants-1997_04 |