8-Hydroxyquinoline → HCID 54673787, compound

Participants

Reaction Conditions

Reaction Steps

The title compound was prepared by method B presented for the compound of Example 1; 2-amino-5-chloro-pyridine, 2-pyridine-carboxaldehyde and 8-hydroxy-quinoline were used in the reaction; the reaction mixture was heated at 60° C. for 3 days. Greyish-white powder, product purified by column chromatography. C20H18ClN4O; (MW: 362.1); yield: 55 mg, (23.7%). m.p.: 160-162° C., HPLC (CH3CN/H2O 70:30 Phenomenex C18 282 nm): 5.69 min.

Provenance & Evidence