HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl propiolate → CGP-47292 methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl propiolate | HCID 13536 | — |
| Reactant | Rufinamide | HCID 129228 | — |
| Reactant | 2-(Azidomethyl)-1,3-difluorobenzene | HCID 10888323 | — |
| Product | CGP-47292 methyl ester | HCID 22716778 | — |
Reaction Steps
WO 2010/043849 describes the process for the preparation of Rufinamide as shown in scheme III below, which comprises the reaction of 2-(azidomethyl)-1, 3-difluorobenzene with methyl propiolate to obtain methyl 1-(2,6-difluorobenzyl)-1H-1,2,3,-triazole-4-carboxylate and which is reacted with ammonia to yield Rufinamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08871945B2 |
| Source dataset | uspto-grants-2014_10 |
| ORD ID | ord-51bdf16c9d7947529084cac6ef779cd4 |
| Source note | uspto-grants-2014_10 |