N2 [3(S)-(benzyloxyformamido)-2(R)-hydroxy-4-(2-naphthyl)butyl]-N1-tert.butyl-L-prolinamide → N2 [3(S)-amino-2(R)-hydroxy-L-(2-naphthyl)butyl]-N1-tert.butyl-L-prolinamide

Participants

Reaction Steps

A solution of 0.725 g of N2 -[3(S)-(benzyloxyformamido)-2(R)-hydroxy-4-(2-naphthyl)butyl]-N1 -tert.butyl-L-prolinamide was dissolved in 25 ml of ethanol and hydrogenated at room temperature and under atmospheric pressure over 0.5 g of 10% palladium-on-carbon for 20 hours. The catalyst was filtered off and the filtrate was evaporated to give 0.54 g of N2 -[3(S)-amino-2(R)-hydroxy-L-(2-naphthyl)butyl]-N1 -tert.butyl-L-prolinamide as a white foam which was used without further purification.

Provenance & Evidence