反应详情

温度

65 °C

Acetic anhydride (3.6 moles) is heated to 100 to 105° C., to which a mixture of crude ethyl difluoroacetoacetate (˜0.96 moles) and triethyl orthoformate (1.8 moles) is added drop-wise. The reaction mixture is kept at 100 to 105° C. for 6 hours. The reaction mixture is cooled to 60 to 70° C. and then concentrated under vacuum to remove excessive acetic anhydride, triethyl orthoformate, and generated ethyl acetate. A pale brown liquid is obtained.

1. additionis added drop-wise
2. concentrationconcentrated under vacuum
3. customto remove excessive acetic anhydride, triethyl orthoformate
4. customA pale brown liquid is obtained