Thionyl Chloride → HCID 178521106, compound

HRID 541057Notes

Reaction equation

HRID 541057 reaction equation
[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([C:10]([OH:12])=O)[C:4]=2[NH:3][CH:2]=1.S(Cl)([Cl:15])=O>>[N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[C:9]([C:10]([Cl:15])=[O:12])[C:4]=2[NH:3][CH:2]=1

Participants

3

Reactant 2

HCID 24386Thionyl Chloride2×HCID 178524253HCID 178524253, compound2×

Product 1

HCID 178521106HCID 178521106, compound

Procedure

The above reaction conditions are as follows: benzimidazole-4-carboxylic acid is reated with thionyl chloride at temperature of 0˜80° C. in a molar molecular ratio of thionyl chloride to benzimidazole-4-carboxylic acid is 1˜20 times, to produce benzimidazole-4-carbonyl chloride, and then benzimidazole-4-carbonyl chloride is reacted with an amine in an organic solvent at temperature of 0˜100° C. to produce benzimidazole-4-carboxamide derivatives. Wherein the organic solvent comprises dichloroethane, 1,1,2-trichloroethane, chloroform, tetrachloroethylene, benzene, toluene, xylene, chlorobenzene or dichlorobenzene, and so on.

Workup

  1. customThe above reaction conditions

Sources & evidence

ORD record
ord-079de858c6df4a3892c7a8d7fb7521a8
Source dataset
uspto-grants-2014_10
Patent number
US08871946B2

Reaction notes

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