Sodium Bicarbonate → HCID 67453478, compound

Participants

Reaction Steps

4 g of 2-n-butyl-3-{4-[3-(di-n-butylamino)-propoxy]-benzoyl}-5-hydroxy-benzofuran hydrochloride (8 mmol) and 16 ml of dichloromethane are placed in an equipped reactor. The reaction medium is stirred until dissolution is obtained. An aqueous sodium bicarbonate solution is added to the reaction medium to pH>7.5 and then the medium is stirred. The phases are decanted off and separated. The aqueous phase is extracted with dichloromethane and then the combined organic phases are washed with a saline solution. After concentration of the organic phase, 3.38 g of 2-n-butyl-3-{4-[3-(di-n-butylamino)-propoxy]-benzoyl}-5-hydroxy-benzofuran are isolated in the form of a brown oil.

Provenance & Evidence