反应详情

温度

180 °C

Under an argon atmosphere, 3-methoxy-indeno[1,2-b]pyridin-5-one (0.545 g) and pyridinium chloride (5.89 g) were mixed with pyridine (1.0 ml). The reaction mixture was stirred with heating at 180° C. for 30 min while evaporating pyridine, and further stirred with heating at 200° C. for 4 hr. The mixture was cooled to room temperature, water was added and the mixture was stirred for 30 min. This slurry was filtered, and the obtained solid was dried under reduced pressure to give the title compound (0.054 g). The obtained solid was used for the next reaction without further purification.

1. customwhile evaporating pyridine
2. stirringfurther stirred
3. temperaturewith heating at 200° C. for 4 hr
4. temperatureThe mixture was cooled to room temperature
5. additionwater was added
6. stirringthe mixture was stirred for 30 min
7. filtrationThis slurry was filtered
8. customthe obtained solid was dried under reduced pressure